Cuyo includes the provinces of Mendoza, San Juan, La Rioja and San Luis. As the rest of the country, this is a varied region with hundreds of landscapes to see.

This is the area of the highest mountain of America, the Aconcagua (6959 m.) and the best wine producers, too. There are also several places that the tourist must visit, as el Valle de la Luna (The Valley of the Moon-San Juan province), El Cañón de Talampaya (The Talampaya Canyon-La Rioja) y el Valle de las Leñas (The Leñas Valley-Mendoza). Being the last one an international skiing resort.

The soil is arid and reddish, crossed by few rivers. Most of the rivers are fed by the thawing of snow on the peaks, and their volume of water increases considerably in spring. The Desaguadero River is the main collector, receiving waters from the Bermejo, Vinchina and Salado before reaching the Colorado River.

Viticulture is one of the main activities of the area. The wine production of the region represents almost 80% of national production, and the wines are highly considered in the world. Olives, potatoes, tomatoes and some fruits are also cultivated, and there is production of sweets and preserved foodstuffs. Quarrying and oil exploitation are other important industries.